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2 article(s) from Neundorf, Ines

Design and biological characterization of novel cell-penetrating peptides preferentially targeting cell nuclei and subnuclear regions

Anja Gronewold,
Mareike Horn and
Ines Neundorf

Beilstein J. Org. Chem. 2018, 14, 1378–1388, doi:10.3762/bjoc.14.116

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Graphical Abstract

Figure 1: Circular dichroism spectra of the novel peptides solved in 10 mM phosphate buffer (pH 7) (A), or ph...

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Figure 2: Cytotoxicity profiles of the peptides in MCF-7 and HeLa cells. Cells were incubated for 24 h with d...

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Figure 3: Cellular uptake in HeLa and MCF-7 cells. Cells were incubated for 30 min with 10 µM of CF-labeled p...

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Figure 4: Cellular uptake in MCF-7 and HeLa cells was quantified by flow cytometry. Cells were incubated with...

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Figure 5: Distribution pattern of the peptides in HeLa and MCF-7 cells when incubating 10 µM CF-labeled pepti...

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Figure 6: Cellular uptake in HeLa and MCF-7 cells when incubating the cells at 4 °C for 30 min with the CF-la...

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Figure 7: Uptake and delivery of DOX into HeLa and MCF-7 cells. Fluorescence microscopic images after 30 min ...

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Full Research Paper

Published 07 Jun 2018

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Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

Jan Hoyer,
Ulrich Schatzschneider,
Michaela Schulz-Siegmund and
Ines Neundorf

Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204

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Figure 1: Flow cytometric uptake studies of carboxyfluorescein-labeled (sC18)₂ in HEK-293 (human embryonic ki...

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Figure 2: Top: Fluorescence microscopic images of unfixed HEK-293 cells after 30 min incubation with 1 µM CF-...

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Figure 3: Cell viability of different cell lines after 24 h incubation with (sC18)₂ at different concentratio...

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Figure 4: Cell lysis of HEK-293 cells induced by (sC18)₂ after 1 h incubation. Experiments were conducted in ...

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Scheme 1: Synthesis of (sC18)₂ bioconjugates (a) and chemical structures of the coupled anti-tumor agents (b)...

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Figure 5: Chromatogram and ESI-MS of purified Cym2-GFL-(sC18)₂. The gradient was 10→60% acetonitrile in water...

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Figure 6: Circular dichroism spectra of the (sC18)₂ conjugates. Spectra were acquired in 10 mM phosphate buff...

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Figure 7: Cell viability of (a) HT-29 and (b) MCF-7 cells after 24 h incubation with the (sC18)₂ conjugates a...

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Figure 8: Brightfield microscopic images of unfixed HT-29 cells after 24 h incubation with the (sC18)₂ conjug...

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Figure 9: Cell lysis of (a) HT-29 and (b) MCF-7 cells induced by the (sC18)₂ conjugates at different concentr...

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Published 18 Oct 2012

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